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Isocitrate dehydrogenase (IDH1) Human Gene Knockout Kit (CRISPR)

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SKU
KN210582LP
IDH1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Isocitrate dehydrogenase or NM_001282386"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Isocitrate dehydrogenase
Locus ID 3417
Components

KN210582G1, Isocitrate dehydrogenase gRNA vector 1 in pCas-Guide CRISPR vector

KN210582G2, Isocitrate dehydrogenase gRNA vector 2 in pCas-Guide CRISPR vector

KN210582LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001282386, NM_001282387, NM_005896, N21575
UniProt ID O75874
Synonyms HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD
Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Sep 2013
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Other Versions
SKU Description Size Price
GA102310 IDH1 CRISPRa kit - CRISPR gene activation of human isocitrate dehydrogenase (NADP(+)) 1, cytosolic 1 kit
$1,657.00
KN210582 IDH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN210582BN IDH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN210582RB IDH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN410582 IDH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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