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PD1 (PDCD1) Human Gene Knockout Kit (CRISPR)

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SKU
KN210364LP
PDCD1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol PD1
Locus ID 5133
Components

KN210364G1, PD1 gRNA vector 1 in pCas-Guide CRISPR vector

KN210364G2, PD1 gRNA vector 2 in pCas-Guide CRISPR vector

KN210364LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_005018
UniProt ID Q15116
Synonyms CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Summary Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. provided by RefSeq, Aug 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA103431 PDCD1 CRISPRa kit - CRISPR gene activation of human programmed cell death 1 1 kit
$1,657.00
KN210364 PDCD1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN210364BN PDCD1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN210364RB PDCD1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN410364 PDCD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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