ApoER2 (LRP8) Human Gene Knockout Kit (CRISPR)

SKU KN208674LP

LRP8 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Vector: Luciferase-Puro
• Target Symbol: ApoER2
• Locus ID: 7804
• Components:

  KN208674G1, ApoER2 gRNA vector 1 in pCas-Guide CRISPR vector

  KN208674G2, ApoER2 gRNA vector 2 in pCas-Guide CRISPR vector

  KN208674LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001018054, NM_004631, NM_017522, NM_033300
• UniProt ID: Q14114
• Synonyms: APOER2; HSZ75190; LRP-8; MCI1
• Summary: This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
• Shipping: Ambient