Human ApoER2 (LRP8) activation kit by CRISPRa

SKU GA105321

LRP8 CRISPRa kit - CRISPR gene activation of human LDL receptor related protein 8

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LRP8
• Locus ID: 7804
• Components:

  GA105321G1, ApoER2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105321G2, ApoER2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105321G3, ApoER2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001018054, NM_004631, NM_017522, NM_033300
• UniProt ID: Q14114
• Synonyms: APOER2; HSZ75190; LRP-8; MCI1
• Summary: This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]