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HCAR2 Human Gene Knockout Kit (CRISPR)

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SKU
KN206527BN
HCAR2 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "HCAR2 or NM_177551"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol HCAR2
Locus ID 338442
Components

KN206527G1, HCAR2 gRNA vector 1 in pCas-Guide CRISPR vector

KN206527G2, HCAR2 gRNA vector 2 in pCas-Guide CRISPR vector

KN206527BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_177551
UniProt ID Q8TDS4
Synonyms GPR109A; HCA2; HM74a; HM74b; NIACR1; Puma-g; PUMAG
Summary Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA117372 HCAR2 CRISPRa kit - CRISPR gene activation of human hydroxycarboxylic acid receptor 2 1 kit
$1,657.00
KN206527 HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206527LP HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206527RB HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN406527 HCAR2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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