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Human HCAR2 activation kit by CRISPRa

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SKU
GA117372
HCAR2 CRISPRa kit - CRISPR gene activation of human hydroxycarboxylic acid receptor 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA351228 Rabbit Polyclonal Anti-HCAR2 Antibody
100 ul
$205.00
RC206527 HCAR2 (Myc-DDK-tagged)-Human G protein-coupled receptor 109A (GPR109A)
10 ug
$457.00

Other products for "HCAR2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HCAR2
Locus ID 338442
Components

GA117372G1, HCAR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA117372G2, HCAR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA117372G3, HCAR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_177551
UniProt ID Q8TDS4
Synonyms GPR109A; HCA2; HM74a; HM74b; NIACR1; Puma-g; PUMAG
Summary Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN206527 HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206527BN HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206527LP HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN206527RB HCAR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN406527 HCAR2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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