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Twist (TWIST1) Human Gene Knockout Kit (CRISPR)

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SKU
KN202920BN
TWIST1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

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RC202920 TWIST1 (Myc-DDK-tagged)-Human twist homolog 1 (Drosophila) (TWIST1)
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GE100003 pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
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Other products for "Twist or NM_000474"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Twist
Locus ID 7291
Components

KN202920G1, Twist gRNA vector 1 in pCas-Guide CRISPR vector

KN202920G2, Twist gRNA vector 2 in pCas-Guide CRISPR vector

KN202920BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000474, NR_149001
UniProt ID Q15672
Synonyms ACS3; bHLHa38; BPES2; BPES3; CRS; CRS1; CSO; SCS; TWIST
Summary This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. provided by RefSeq, Jul 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA105021 TWIST1 CRISPRa kit - CRISPR gene activation of human twist family bHLH transcription factor 1 1 kit
$1,657.00
KN202920 TWIST1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202920LP TWIST1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202920RB TWIST1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402920 TWIST1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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