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MECP2 Human Gene Knockout Kit (CRISPR)

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SKU
KN202382RB
MECP2 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "MECP2 or NM_001110792"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol MECP2
Locus ID 4204
Components

KN202382G1, MECP2 gRNA vector 1 in pCas-Guide CRISPR vector

KN202382G2, MECP2 gRNA vector 2 in pCas-Guide CRISPR vector

KN202382RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001110792, NM_001316337, NM_004992, NM_001369391, NM_001369394, NM_001369392, NM_001369393
UniProt ID P51608
Synonyms AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
Summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Oct 2015
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Other Versions
SKU Description Size Price
GA102863 MECP2 CRISPRa kit - CRISPR gene activation of human methyl-CpG binding protein 2 1 kit
$1,657.00
KN202382 MECP2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202382BN MECP2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202382LP MECP2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402382 MECP2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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