CREB1 Human Gene Knockout Kit (CRISPR)

SKU KN202115BN

CREB1 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: CREB1
• Locus ID: 1385
• Components:

  KN202115G1, CREB1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN202115G2, CREB1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN202115BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_004379, NM_134442, NM_001320793, NR_135473
• UniProt ID: P16220
• Synonyms: CREB
• Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
• Shipping: Ambient