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IL1 beta (IL1B) Human Gene Knockout Kit (CRISPR)

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SKU
KN202079BN
IL1B - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "IL1 beta or NM_000576"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol IL1 beta
Locus ID 3553
Components

KN202079G1, IL1 beta gRNA vector 1 in pCas-Guide CRISPR vector

KN202079G2, IL1 beta gRNA vector 2 in pCas-Guide CRISPR vector

KN202079BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000576
UniProt ID P01584
Synonyms IL-1; IL1-BETA; IL1F2
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. provided by RefSeq, Jul 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA102372 IL1B CRISPRa kit - CRISPR gene activation of human interleukin 1 beta 1 kit
$1,657.00
KN202079 IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202079LP IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202079RB IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402079 IL1B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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