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Human IL1 beta (IL1B) activation kit by CRISPRa

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SKU
GA102372
IL1B CRISPRa kit - CRISPR gene activation of human interleukin 1 beta
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA506443 IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1) 100 ul
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Other products for "IL1B"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol IL1B
Locus ID 3553
Components

GA102372G1, IL1 beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102372G2, IL1 beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102372G3, IL1 beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000576
UniProt ID P01584
Synonyms IL-1; IL1-BETA; IL1F2
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. provided by RefSeq, Jul 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN202079 IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202079BN IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202079LP IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202079RB IL1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402079 IL1B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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