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p21 (CDKN1A) Human Gene Knockout Kit (CRISPR)

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SKU
KN201765RB
CDKN1A - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "p21 or NM_000389"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol p21
Locus ID 1026
Components

KN201765G1, p21 gRNA vector 1 in pCas-Guide CRISPR vector

KN201765G2, p21 gRNA vector 2 in pCas-Guide CRISPR vector

KN201765RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000389, NM_001220777, NM_001220778, NM_001291549, NM_078467, NR_037150, NR_037151, NR_037152
UniProt ID P38936
Synonyms CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
Summary This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. provided by RefSeq, Sep 2015
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Other Versions
SKU Description Size Price
GA100738 CDKN1A CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 1A 1 kit
$1,657.00
KN201765 CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201765BN CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201765LP CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401765 CDKN1A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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