OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Human p21 (CDKN1A) activation kit by CRISPRa

Be the first to review this product
SKU
GA100738
CDKN1A CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 1A
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA808164 CDKN1A mouse monoclonal antibody, clone OTI7C8 (formerly 7C8) 100 ul
$447.00
RC201765 CDKN1A (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2
10 ug
$225.00

Other products for "CDKN1A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CDKN1A
Locus ID 1026
Components

GA100738G1, p21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100738G2, p21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100738G3, p21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_000389, NM_001220777, NM_001220778, NM_001291549, NM_078467, NR_037150, NR_037151, NR_037152
UniProt ID P38936
Synonyms CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
Summary This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. provided by RefSeq, Sep 2015
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources
Other Versions
SKU Description Size Price
KN201765 CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201765BN CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201765LP CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201765RB CDKN1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401765 CDKN1A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products