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p21 (CDKN1A) Mouse Monoclonal Antibody [Clone ID: OTI7C8]

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SKU
TA808164
CDKN1A mouse monoclonal antibody, clone OTI7C8 (formerly 7C8)
Size:
100 ul 30 ul
Conjugation:
Unconjugated
  $447.00
In Stock*
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View other "p21 or NM_078467" antibodies

Specifications
Specifications
Product Data
Clone Name OTI7C8
Application IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Human
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 2-164 of human CDKN1A(NP_510867) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 17.9 kDa
Gene Name cyclin-dependent kinase inhibitor 1A
Database Link
Background This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. provided by RefSeq, Nov 2010
Synonyms CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
Reference Data
Protein Categories Cancer: Gynecologic, Growth Factors, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer
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Other "OTI7C8" antibodies (1)
SKU Description Size Price
TA808164S CDKN1A mouse monoclonal antibody, clone OTI7C8 (formerly 7C8) 30 ul
$200.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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