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Human Chk2 (CHEK2) activation kit by CRISPRa

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SKU
GA107718
CHEK2 CRISPRa kit - CRISPR gene activation of human checkpoint kinase 2
  $1,657.00
4 Weeks*

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Other products for "CHEK2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CHEK2
Locus ID 11200
Components

GA107718G1, Chk2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107718G2, Chk2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107718G3, Chk2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001005735, NM_001257387, NM_007194, NM_145862, NM_001349956
UniProt ID O96017
Synonyms CDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
Summary In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Apr 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN201278 CHEK2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201278BN CHEK2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201278LP CHEK2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201278RB CHEK2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401278 CHEK2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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