Chk2 (CHEK2) Mouse Monoclonal Antibody [Clone ID: OTI5C4]

SKU
TA500398
CHEK2 (CHK2) mouse monoclonal antibody, clone OTI5C4 (formerly 5C4)
  • TrueMAB

    Antibodies made against full-length proteins as antigens.

    Click here to learn more.

$447.00
In Stock*
Specifications
Product Data
Clone Name OTI5C4
Application FC, IF, IHC, IP, WB
Recommended Dilution WB 1:500~1000, IHC 1:150, IF 1:50~100, FLOW 1:100, IP 2ug/500ul
Reactivity Dog, Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human CHEK2 (NP_009125) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1.43 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 60.7 kDa
Gene Name checkpoint kinase 2
Database Link
Background In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms CDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
Reference Data
Protein Families Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways Cell cycle, p53 signaling pathway
Write Your Own Review
You're reviewing:Chk2 (CHEK2) Mouse Monoclonal Antibody [Clone ID: OTI5C4]
Your Rating
SKU Description Size Price
CF500398 Carrier-free (BSA/glycerol-free) CHEK2 mouse monoclonal antibody, clone OTI5C4 (formerly 5C4) 100 ug
$600.00
TA500398AM CHEK2 mouse monoclonal antibody, clone 5C4, Biotinylated 100 ul
$509.00
TA500398BM CHEK2 mouse monoclonal antibody, clone 5C4, HRP conjugated 100 ul
$509.00
TA500398S CHEK2 (CHK2) mouse monoclonal antibody, clone OTI5C4 (formerly 5C4) 30 ul
$200.00

Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.