Human PRMT5 activation kit by CRISPRa

SKU GA107102

PRMT5 CRISPRa kit - CRISPR gene activation of human protein arginine methyltransferase 5

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRMT5
• Locus ID: 10419
• Components:

  GA107102G1, PRMT5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107102G2, PRMT5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107102G3, PRMT5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001039619, NM_001282953, NM_001282954, NM_001282955, NM_001282956, NM_006109
• UniProt ID: O14744
• Synonyms: HRMT1L5; IBP72; JBP1; SKB1; SKB1Hs
• Summary: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]