Human ERK5 (MAPK7) activation kit by CRISPRa

SKU GA103788

MAPK7 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase 7

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MAPK7
• Locus ID: 5598
• Components:

  GA103788G1, ERK5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103788G2, ERK5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103788G3, ERK5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002749, NM_139032, NM_139033, NM_139034
• UniProt ID: Q13164
• Synonyms: BMK1; ERK4; ERK5; PRKM7
• Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]