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Human MET activation kit by CRISPRa

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SKU
GA102883
MET CRISPRa kit - CRISPR gene activation of human MET proto-oncogene, receptor tyrosine kinase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA805795 MET mouse monoclonal antibody, clone OTI1E6 (formerly 1E6) 100 ul
$447.00
RC217003 MET (Myc-DDK-tagged)-Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2
10 ug
$1,783.00

Other products for "MET"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol MET
Locus ID 4233
Components

GA102883G1, MET gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102883G2, MET gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102883G3, MET gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000245, NM_001127500, NM_001324401, NM_001324402
UniProt ID P08581
Synonyms AUTS9; c-Met; DFNB97; HGFR; RCCP2
Summary This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. provided by RefSeq, May 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN217003 MET - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217003BN MET - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217003LP MET - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217003RB MET - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN417003 MET - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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