Human Integrin beta 4 binding protein (EIF6) activation kit by CRISPRa

SKU GA102481

EIF6 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 6

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: EIF6
• Locus ID: 3692
• Components:

  GA102481G1, Integrin beta 4 binding protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102481G2, Integrin beta 4 binding protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102481G3, Integrin beta 4 binding protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001267810, NM_002212, NM_181466, NM_181467, NM_181468, NM_181469, NR_052022, NR_052023, NR_052024
• UniProt ID: P56537
• Synonyms: b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP; p27(BBP); p27BBP
• Summary: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]