IGF1 Receptor (IGF1R) (NM_000875) Human Tagged ORF Clone
$789.00
$1,954.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | IGF1 Receptor |
| Synonyms | CD221; IGFIR; IGFR; JTK13 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_000875 |
| ORF Size | 4101 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000875.2, NP_000866.1 |
| RefSeq Size | 4989 bp |
| RefSeq ORF | 4104 bp |
| Locus ID | 3480 |
| UniProt ID | P08069 |
| Cytogenetics | 15q26.3 |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer |
| Summary | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. provided by RefSeq, May 2014 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000875" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC214928 | IGF1R (Myc-DDK-tagged)-Human insulin-like growth factor 1 receptor (IGF1R) | 10 ug |
$1,754.00
|
|
| RC214928L1 | Lenti ORF clone of Human insulin-like growth factor 1 receptor (IGF1R), Myc-DDK-tagged | 10 ug |
$2,054.00
|
|
| RC214928L2 | Lenti ORF clone of Human insulin-like growth factor 1 receptor (IGF1R), mGFP tagged | 10 ug |
$2,054.00
|
|
| RC214928L3 | Lenti ORF clone of Human insulin-like growth factor 1 receptor (IGF1R), Myc-DDK-tagged | 10 ug |
$2,054.00
|
|
| RC214928L4 | Lenti ORF clone of Human insulin-like growth factor 1 receptor (IGF1R), mGFP tagged | 10 ug |
$2,054.00
|
|
| RC600009 | IGF1R (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens insulin-like growth factor 1 receptor, Signal peptide (1-30) plus EC domain (741-935) | 10 ug |
$589.00
$1,170.00
|
|
| SC124152 | IGF1R (untagged)-Human insulin-like growth factor 1 receptor (IGF1R) | 10 ug |
$1,755.00
|
|
Citations
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis
Chakraborty, Bhat, Mushtaq et al
Commun Biol (2023) 6 (1), 758 DOI: 10.1038/s42003-023-05125-1
Chakraborty, Bhat, Mushtaq et al
Commun Biol (2023) 6 (1), 758 DOI: 10.1038/s42003-023-05125-1
Cited by 14
AI Summary: In this study, OriGene's EHD1 shRNA (TG311361) and mouse Ehd1 cDNA clone (MR200761) were used to manipulate EHD1 expression, enabling the authors to demonstrate EHD1's essential role in IGF-1R trafficking and Ewing sarcoma tumorigenesis.
Snippet: Overexpression of the EPS15 Homology Domain containing 1 (EHD1) protein has been linked to tumorigenesis but whether its core function as a regulator of intracellular traffic of cell surface receptors plays a role in oncogenesis remains unknown. We establish that EHD1 is overexpressed in Ewing sarcoma (EWS), with high EHD1 mRNA expression specifying shorter patient survival. ShRNA-knockdown and CR...
Insulin-like growth factor-I induces chemoresistence to docetaxel by inhibiting miR-143 in human prostate cancer
Niu, Fu, Wang et al
Oncotarget (2017) 8 (63), 107157-107166 DOI: 10.18632/oncotarget.22362
Niu, Fu, Wang et al
Oncotarget (2017) 8 (63), 107157-107166 DOI: 10.18632/oncotarget.22362
Snippet: For plasmid transient transfection, PC-3 cells stably expressing miR-143 or negative control were co-transfected with VEGF reporter [40], pRL-TK vector plasmid without (pCMV6 vector alone) or with pCMV6-IGF-IR or pCMV6-IRS1 plasmid (OriGene Technologies, Rockville
Showing 1-2 of 2 papers.
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