IGF1 Receptor (IGF1R) Mouse Monoclonal Antibody [Clone ID: OTI4C4]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI4C4 |
|---|---|
| Application | FC, WB |
| Recommended Dilution | WB 1:2000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 741-935 of human IGF1R(NP_000866) produced in Insect. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 81 kDa |
| Gene Name | insulin like growth factor 1 receptor |
| Database Link | |
| Background | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May |
| Synonyms | CD221; IGFIR; IGFR; JTK13 |
| Reference Data | |
| Protein Categories | ADC Targets, Cancer: Gastrointestinal, Cancer: Lung, Cancer: Sarcoma, CD Markers, Cytokines, Endocrine and metabolic diseases, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4C4" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF807835 | Carrier-free (BSA/glycerol-free) IGF1R mouse monoclonal antibody, clone OTI4C4 (formerly 4C4) | 100 ug |
$620.00
|
|
| TA807835AM | IGF1R mouse monoclonal antibody, clone OTI4C4 (formerly 4C4), Biotinylated | 100 ul |
$509.00
|
|
| TA807835BM | IGF1R mouse monoclonal antibody, clone OTI4C4 (formerly 4C4), HRP conjugated | 100 ul |
$509.00
|
|
| TA807835S | IGF1R mouse monoclonal antibody, clone OTI4C4 (formerly 4C4) | 30 ul |
$200.00
|
|
Citations
Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface
Ye, Chan, Waters et al
Oncotarget (2016) 7 (52), 86948-86971 DOI: 10.18632/oncotarget.13566
Ye, Chan, Waters et al
Oncotarget (2016) 7 (52), 86948-86971 DOI: 10.18632/oncotarget.13566
Snippet: anti-ANTXR1, anti-BSG, anti-IGF1R, anti-PTPRJ, anti-SOS2, anti-CELSR1, anti-SLC9A7, and anti-TGFBR2 were from OriGene Technologies (Rockville, MD)
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