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CD33 Human Recombinant Protein

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SKU
TP723960
Recombinant human CD33 protein with C-terminal human Fc and 6×His tag
Size:
100 ug
  $770.00
4 Weeks*
Bulk/Customize

Frequently Bought Together (1)

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Other products for "CD33"

Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
CD33(Asp18-His259) hFc(Glu99-Ala330) 6×His tag
Tag C-Human Fc and 6×His Tag
Predicted MW The protein has a predicted molecular mass of 53.8 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Preparation Affinity purification
Storage Store the lyophilized protein at -20°C.
After reconstitution, store the protein at -80°C for 12 months.
Avoid repeated freezing and thawing.
Stability 12 months from date of despatch
Shipping Ambient
Reference Data
Locus ID 945
UniProt ID P20138
Synonyms CD33;SIGLEC3;gp67
Summary Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Protein Categories ADC Targets, CAR-T Targets, CD Markers, Cytokines, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Hematopoietic cell lineage
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Other "CD33" proteins (13)
SKU Description Size Price
PH307023 CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001763) 10 ug
$3,360.00
PH317716 CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001076087) 10 ug
$3,360.00
LC400667 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC421195 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC425947 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC432863 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400667 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY421195 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY425947 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY432863 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 3 (as WB positive control) 100 ug
$436.00
TP307023 Recombinant protein of human CD33 molecule (CD33), transcript variant 1, 20 µg 20 ug
$737.00
TP317716 Purified recombinant protein of Homo sapiens CD33 molecule (CD33), transcript variant 2, 20 µg 20 ug
$737.00
TP720665 Purified recombinant protein of Human CD33 molecule (CD33), transcript variant 1 10 ug
$235.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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