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CD33 (NM_001772) Human Recombinant Protein

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SKU
TP720665
Purified recombinant protein of Human CD33 molecule (CD33), transcript variant 1
Size:
10 ug 500 ug 50 ug
  $235.00
5 Days*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Asp18-His259
Tag C-hFc&His
Predicted MW 55.01 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 um filtered solution of PBS, 5% Trehalose, 0.01%Tween 80, pH7.2
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reconstitution Method Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Ambient
Reference Data
RefSeq NP_001763
Locus ID 945
UniProt ID P20138
Cytogenetics 19q13.41
RefSeq Size 1466
RefSeq ORF 1092
Synonyms p67; SIGLEC-3; SIGLEC3
Summary Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).UniProtKB/Swiss-Prot Function
Protein Categories ADC Targets, CAR-T Targets, CD Markers, Cytokines, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Hematopoietic cell lineage
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Other "CD33" proteins (13)
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PH307023 CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001763) 10 ug
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LC400667 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LC421195 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LC425947 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LC432863 Lyophilized CD33 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LY400667 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 1 (as WB positive control) 100 ug
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LY421195 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 (as WB positive control) 100 ug
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LY425947 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 (as WB positive control) 100 ug
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LY432863 Transient overexpression lysate of CD33 molecule (CD33), transcript variant 3 (as WB positive control) 100 ug
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TP307023 Recombinant protein of human CD33 molecule (CD33), transcript variant 1, 20 µg 20 ug
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TP317716 Purified recombinant protein of Homo sapiens CD33 molecule (CD33), transcript variant 2, 20 µg 20 ug
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TP723960 Recombinant human CD33 protein with C-terminal human Fc and 6×His tag 100 ug
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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