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Padi4 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN312748LP
Padi4 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

MR216758 Padi4 (Myc-DDK-tagged) - Mouse peptidyl arginine deiminase, type IV (Padi4)
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TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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Other products for "Padi4 or NM_011061"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Padi4
Locus ID 18602
Components

KN312748G1, Padi4 gRNA vector 1 in pCas-Guide CRISPR vector

KN312748G2, Padi4 gRNA vector 2 in pCas-Guide CRISPR vector

KN312748LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_011061
UniProt ID Q9Z183
Synonyms Pad4; Pdi4
Summary Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
GA203161 Padi4 CRISPRa kit - CRISPR gene activation of mouse peptidyl arginine deiminase, type IV 1 kit
$1,657.00
KN312748 Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN312748BN Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN312748RB Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN512748 Padi4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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