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Mouse Padi4 activation kit by CRISPRa

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SKU
GA203161
Padi4 CRISPRa kit - CRISPR gene activation of mouse peptidyl arginine deiminase, type IV
  $1,657.00
4 Weeks*

Other products for "Padi4"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Padi4
Locus ID 18602
Components

GA203161G1, Padi4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA203161G2, Padi4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA203161G3, Padi4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_011061
UniProt ID Q9Z183
Synonyms Pad4; Pdi4
Summary Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN312748 Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN312748BN Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN312748LP Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN312748RB Padi4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN512748 Padi4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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