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Myo18a Mouse Gene Knockout Kit (CRISPR)

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SKU
KN310624RB
Myo18a - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

MR224798 Myo18a (Myc-DDK-tagged) - Mouse myosin XVIIIA (Myo18a)
10 ug
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TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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Other products for "Myo18a or NM_001291212"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Myo18a
Locus ID 360013
Components

KN310624G1, Myo18a gRNA vector 1 in pCas-Guide CRISPR vector

KN310624G2, Myo18a gRNA vector 2 in pCas-Guide CRISPR vector

KN310624RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001291212, NM_001291213, NM_001291214, NM_001291215, NM_011586
UniProt ID Q9JMH9
Synonyms MAJN; MyoPDZ; MysPDZ; SP-R210
Summary May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (PubMed:10733906). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (By similarity).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA216981 Myo18a CRISPRa kit - CRISPR gene activation of mouse myosin XVIIIA 1 kit
$1,657.00
KN310624 Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310624BN Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310624LP Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN510624 Myo18a - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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