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Mouse Myo18a activation kit by CRISPRa

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SKU
GA216981
Myo18a CRISPRa kit - CRISPR gene activation of mouse myosin XVIIIA
  $1,657.00
4 Weeks*

Other products for "Myo18a"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Myo18a
Locus ID 360013
Components

GA216981G1, Myo18a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA216981G2, Myo18a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA216981G3, Myo18a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001291212, NM_001291213, NM_001291214, NM_001291215, NM_011586
UniProt ID Q9JMH9
Synonyms MAJN; MyoPDZ; MysPDZ; SP-R210
Summary May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (PubMed:10733906). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN310624 Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310624BN Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310624LP Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310624RB Myo18a - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN510624 Myo18a - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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