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Lair1 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN309105LP
Lair1 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

MR203475 Lair1 (Myc-DDK-tagged) - Mouse leukocyte-associated Ig-like receptor 1 (Lair1), transcript variant a
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Other products for "Lair1 or BC025901"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Lair1
Locus ID 52855
Components

KN309105G1, Lair1 gRNA vector 1 in pCas-Guide CRISPR vector

KN309105G2, Lair1 gRNA vector 2 in pCas-Guide CRISPR vector

KN309105LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001113474, NM_001302675, NM_001302676, NM_001302677, NM_001302681, NM_001302682, NM_001302683, NM_178611
UniProt ID Q8BG84
Synonyms 5133400O11Rik; BB115266; D7Bwg0421e; Lair-1
Summary Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA205527 Lair1 CRISPRa kit - CRISPR gene activation of mouse leukocyte-associated Ig-like receptor 1 1 kit
$1,657.00
KN309105 Lair1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN309105BN Lair1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN309105RB Lair1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN509105 Lair1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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