Cxcl5 Mouse Gene Knockout Kit (CRISPR)

CAT#: KN304047BN

Cxcl5 - mouse gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: Cxcl5
• Locus ID: 20311
• Components:

  KN304047G1, Cxcl5 gRNA vector 1 in pCas-Guide CRISPR vector

  KN304047G2, Cxcl5 gRNA vector 2 in pCas-Guide CRISPR vector

  KN304047BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_009141
• UniProt ID: P50228
• Synonyms: AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5; Scyb6
• Summary: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]