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Angptl4 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN301242RB
Angptl4 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Angptl4 or BC006611"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Angptl4
Locus ID 57875
Components

KN301242G1, Angptl4 gRNA vector 1 in pCas-Guide CRISPR vector

KN301242G2, Angptl4 gRNA vector 2 in pCas-Guide CRISPR vector

KN301242RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_020581
UniProt ID Q9Z1P8
Synonyms Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg; Pp1158
Summary Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:15837923, PubMed:17609370, PubMed:29899519). May also play a role in regulating glucose homeostasis and insulin sensitivity (PubMed:15837923, PubMed:29899519). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17130448, PubMed:21832056). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (Probable).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA206235 Angptl4 CRISPRa kit - CRISPR gene activation of mouse angiopoietin-like 4 1 kit
$1,657.00
KN301242 Angptl4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301242BN Angptl4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301242LP Angptl4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN501242 Angptl4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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