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Aifm1 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN301038LP
Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Aifm1 or BC003292"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Aifm1
Locus ID 26926
Components

KN301038G1, Aifm1 gRNA vector 1 in pCas-Guide CRISPR vector

KN301038G2, Aifm1 gRNA vector 2 in pCas-Guide CRISPR vector

KN301038LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001290364, NM_012019
UniProt ID Q9Z0X1
Synonyms AIF; AIFsh2; Hq; Pdcd8
Summary Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA205043 Aifm1 CRISPRa kit - CRISPR gene activation of mouse apoptosis-inducing factor, mitochondrion-associated 1 1 kit
$1,657.00
KN301038 Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301038BN Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301038RB Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN501038 Aifm1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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