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Mouse Aifm1 activation kit by CRISPRa

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SKU
GA205043
Aifm1 CRISPRa kit - CRISPR gene activation of mouse apoptosis-inducing factor, mitochondrion-associated 1
  $1,657.00
4 Weeks*

Other products for "Aifm1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Aifm1
Locus ID 26926
Components

GA205043G1, Aifm1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA205043G2, Aifm1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA205043G3, Aifm1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001290364, NM_012019
UniProt ID Q9Z0X1
Synonyms AIF; AIFsh2; Hq; Pdcd8
Summary Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN301038 Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301038BN Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301038LP Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301038RB Aifm1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN501038 Aifm1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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