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Tcim Mouse Gene Knockout Kit (CRISPR)

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SKU
KN300185LP
1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Tcim or BC016562"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Tcim
Locus ID 69068
Components

KN300185G1, Tcim gRNA vector 1 in pCas-Guide CRISPR vector

KN300185G2, Tcim gRNA vector 2 in pCas-Guide CRISPR vector

KN300185LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_026931
UniProt ID Q9D915
Synonyms 1110065B09Rik; AW121743; AW321058
Summary Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA208041 Tcim CRISPRa kit - CRISPR gene activation of mouse transcriptional and immune response regulator 1 kit
$1,657.00
KN300185 1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN300185BN 1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN300185RB 1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN500185 1810011O10Rik - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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