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NOTCH3 Human Gene Knockout Kit (CRISPR)

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SKU
KN224711BN
NOTCH3 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "NOTCH3 or NM_000435"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol NOTCH3
Locus ID 4854
Components

KN224711G1, NOTCH3 gRNA vector 1 in pCas-Guide CRISPR vector

KN224711G2, NOTCH3 gRNA vector 2 in pCas-Guide CRISPR vector

KN224711BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000435
UniProt ID Q9UM47
Synonyms CADASIL; CADASIL1; CASIL; IMF2; LMNS
Summary This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
GA103241 NOTCH3 CRISPRa kit - CRISPR gene activation of human notch receptor 3 1 kit
$1,657.00
KN224711 NOTCH3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN224711LP NOTCH3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN224711RB NOTCH3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN424711 NOTCH3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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