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CYP27B1 Human Gene Knockout Kit (CRISPR)

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SKU
KN222840LP
CYP27B1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "CYP27B1 or NM_000785"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol CYP27B1
Locus ID 1594
Components

KN222840G1, CYP27B1 gRNA vector 1 in pCas-Guide CRISPR vector

KN222840G2, CYP27B1 gRNA vector 2 in pCas-Guide CRISPR vector

KN222840LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000785
UniProt ID O15528
Synonyms CP2B; CYP1; CYP1alpha; CYP27B; P450c1; PDDR; VDD1; VDDR; VDDRI; VDR
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. provided by RefSeq, Jul 2008
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Other Versions
SKU Description Size Price
GA101122 CYP27B1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 27 subfamily B member 1 1 kit
$1,657.00
KN222840 CYP27B1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN222840BN CYP27B1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN222840RB CYP27B1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN422840 CYP27B1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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