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NOTCH4 Human Gene Knockout Kit (CRISPR)

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SKU
KN221762RB
NOTCH4 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "NOTCH4 or NM_004557"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol NOTCH4
Locus ID 4855
Components

KN221762G1, NOTCH4 gRNA vector 1 in pCas-Guide CRISPR vector

KN221762G2, NOTCH4 gRNA vector 2 in pCas-Guide CRISPR vector

KN221762RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_004557, NR_134949, NR_134950
UniProt ID Q99466
Synonyms INT3
Summary This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. provided by RefSeq, Jan 2016
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Other Versions
SKU Description Size Price
GA103242 NOTCH4 CRISPRa kit - CRISPR gene activation of human notch receptor 4 1 kit
$1,657.00
KN221762 NOTCH4 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221762BN NOTCH4 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221762LP NOTCH4 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN421762 NOTCH4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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