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Wilms Tumor Protein (WT1) Human Gene Knockout Kit (CRISPR)

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SKU
KN220079LP
WT1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Wilms Tumor Protein or NM_000378"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Wilms Tumor Protein
Locus ID 7490
Components

KN220079G1, Wilms Tumor Protein gRNA vector 1 in pCas-Guide CRISPR vector

KN220079G2, Wilms Tumor Protein gRNA vector 2 in pCas-Guide CRISPR vector

KN220079LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000378, NM_001198551, NM_001198552, NM_024424, NM_024425, NM_024426, NM_001367854, NR_160306
UniProt ID P19544
Synonyms AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33
Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. provided by RefSeq, Mar 2015
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Documents
Resources
Other Versions
SKU Description Size Price
GA105163 WT1 CRISPRa kit - CRISPR gene activation of human WT1 transcription factor 1 kit
$1,657.00
KN220079 WT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220079BN WT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220079RB WT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN420079 WT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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