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Leptin Receptor (LEPR) Human Gene Knockout Kit (CRISPR)

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SKU
KN218456BN
LEPR - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Leptin Receptor or NM_001003679"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Leptin Receptor
Locus ID 3953
Components

KN218456G1, Leptin Receptor gRNA vector 1 in pCas-Guide CRISPR vector

KN218456G2, Leptin Receptor gRNA vector 2 in pCas-Guide CRISPR vector

KN218456BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001003679, NM_001003680, NM_001198687, NM_001198688, NM_001198689, NM_002303
UniProt ID P48357
Synonyms CD295; LEP-R; LEPRD; OB-R; OBR
Summary The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).provided by RefSeq, Nov 2010
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Other Versions
SKU Description Size Price
GA102678 LEPR CRISPRa kit - CRISPR gene activation of human leptin receptor 1 kit
$1,657.00
KN218456 LEPR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN218456LP LEPR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN218456RB LEPR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN418456 LEPR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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