beta 1 Adrenergic Receptor (ADRB1) Human Gene Knockout Kit (CRISPR)

SKU KN217134LP

ADRB1 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Vector: Luciferase-Puro
• Target Symbol: beta 1 Adrenergic Receptor
• Locus ID: 153
• Components:

  KN217134G1, beta 1 Adrenergic Receptor gRNA vector 1 in pCas-Guide CRISPR vector

  KN217134G2, beta 1 Adrenergic Receptor gRNA vector 2 in pCas-Guide CRISPR vector

  KN217134LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_000684
• UniProt ID: P08588
• Synonyms: ADRB1R; B1AR; BETA1AR; RHR
• Summary: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]
• Shipping: Ambient