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CD45 (PTPRC) Human Gene Knockout Kit (CRISPR)

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SKU
KN216590BN
PTPRC - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "CD45 or NM_001267798"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol CD45
Locus ID 5788
Components

KN216590G1, CD45 gRNA vector 1 in pCas-Guide CRISPR vector

KN216590G2, CD45 gRNA vector 2 in pCas-Guide CRISPR vector

KN216590BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001267798, NM_002838, NM_080921, NM_080922, NM_080923, NR_052021
UniProt ID P08575
Synonyms B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. provided by RefSeq, Jun 2012
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Documents
Resources
Other Versions
SKU Description Size Price
GA103932 PTPRC CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type C 1 kit
$1,657.00
KN216590 PTPRC - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216590LP PTPRC - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216590RB PTPRC - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN416590 PTPRC - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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