LRRK2 Human Gene Knockout Kit (CRISPR)

SKU KN216373RB

LRRK2 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Vector: RFP-BSD
• Target Symbol: LRRK2
• Locus ID: 120892
• Components:

  KN216373G1, LRRK2 gRNA vector 1 in pCas-Guide CRISPR vector

  KN216373G2, LRRK2 gRNA vector 2 in pCas-Guide CRISPR vector

  KN216373RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_198578
• UniProt ID: Q5S007
• Synonyms: AURA17; DARDARIN; PARK8; RIPK7; ROCO2
• Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
• Shipping: Ambient