Human LRRK2 activation kit by CRISPRa

SKU GA114729

LRRK2 CRISPRa kit - CRISPR gene activation of human leucine rich repeat kinase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LRRK2
• Locus ID: 120892
• Components:

  GA114729G1, LRRK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114729G2, LRRK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114729G3, LRRK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_198578
• UniProt ID: Q5S007
• Synonyms: AURA17; DARDARIN; PARK8; RIPK7; ROCO2
• Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]