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TJP1 Human Gene Knockout Kit (CRISPR)

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SKU
KN216224BN
TJP1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "TJP1 or NM_001301025"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol TJP1
Locus ID 7082
Components

KN216224G1, TJP1 gRNA vector 1 in pCas-Guide CRISPR vector

KN216224G2, TJP1 gRNA vector 2 in pCas-Guide CRISPR vector

KN216224BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001301025, NM_001301026, NM_003257, NM_175610, NM_001330239, NM_001355012, NM_001355013, NM_001355014, NM_001355015
UniProt ID Q07157
Synonyms ZO-1
Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Aug 2017
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Documents
Resources
Other Versions
SKU Description Size Price
GA104884 TJP1 CRISPRa kit - CRISPR gene activation of human tight junction protein 1 1 kit
$1,657.00
KN216224 TJP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216224LP TJP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216224RB TJP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN416224 TJP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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