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ZNF451 Human Gene Knockout Kit (CRISPR)

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SKU
KN215720BN
ZNF451 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "ZNF451 or NM_001031623"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol ZNF451
Locus ID 26036
Components

KN215720G1, ZNF451 gRNA vector 1 in pCas-Guide CRISPR vector

KN215720G2, ZNF451 gRNA vector 2 in pCas-Guide CRISPR vector

KN215720BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001031623, NM_001257273, NM_015555
UniProt ID Q9Y4E5
Synonyms COASTER; dJ417I1.1
Summary E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA108711 ZNF451 CRISPRa kit - CRISPR gene activation of human zinc finger protein 451 1 kit
$1,657.00
KN215720 ZNF451 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215720LP ZNF451 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215720RB ZNF451 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN415720 ZNF451 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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