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ATRX Human Gene Knockout Kit (CRISPR)

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SKU
KN215176BN
ATRX - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "ATRX or NM_000489"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol ATRX
Locus ID 546
Components

KN215176G1, ATRX gRNA vector 1 in pCas-Guide CRISPR vector

KN215176G2, ATRX gRNA vector 2 in pCas-Guide CRISPR vector

KN215176BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000489, NM_138270, NM_138271
UniProt ID P46100
Synonyms ATR2; JMS; MRX52; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX
Summary The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. provided by RefSeq, Jul 2017
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Documents
Resources
Other Versions
SKU Description Size Price
GA100377 ATRX CRISPRa kit - CRISPR gene activation of human ATRX chromatin remodeler 1 kit
$1,657.00
KN215176 ATRX - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215176LP ATRX - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215176RB ATRX - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN415176 ATRX - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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