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NOTCH2 Human Gene Knockout Kit (CRISPR)

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SKU
KN215107BN
NOTCH2 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "NOTCH2 or NM_001200001"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol NOTCH2
Locus ID 4853
Components

KN215107G1, NOTCH2 gRNA vector 1 in pCas-Guide CRISPR vector

KN215107G2, NOTCH2 gRNA vector 2 in pCas-Guide CRISPR vector

KN215107BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001200001, NM_024408
UniProt ID Q04721
Synonyms AGS2; HJCYS; hN2
Summary This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jan 2011
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Documents
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Other Versions
SKU Description Size Price
GA103240 NOTCH2 CRISPRa kit - CRISPR gene activation of human notch receptor 2 1 kit
$1,657.00
KN215107 NOTCH2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215107LP NOTCH2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215107RB NOTCH2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN415107 NOTCH2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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