Paxillin (PXN) Human Gene Knockout Kit (CRISPR)

SKU KN213811BN

PXN - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: Paxillin
• Locus ID: 5829
• Components:

  KN213811G1, Paxillin gRNA vector 1 in pCas-Guide CRISPR vector

  KN213811G2, Paxillin gRNA vector 2 in pCas-Guide CRISPR vector

  KN213811BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001080855, NM_001243756, NM_002859, NM_025157
• UniProt ID: P49023
• Synonyms: FLJ16691
• Summary: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
• Shipping: Ambient