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HMGCR Human Gene Knockout Kit (CRISPR)

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SKU
KN213184BN
HMGCR - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "HMGCR or NM_000859"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol HMGCR
Locus ID 3156
Components

KN213184G1, HMGCR gRNA vector 1 in pCas-Guide CRISPR vector

KN213184G2, HMGCR gRNA vector 2 in pCas-Guide CRISPR vector

KN213184BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000859, NM_001130996, NM_001364187
UniProt ID P04035
Synonyms LDLCQ3
Summary HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Aug 2008
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Other Versions
SKU Description Size Price
GA102151 HMGCR CRISPRa kit - CRISPR gene activation of human 3-hydroxy-3-methylglutaryl-CoA reductase 1 kit
$1,657.00
KN213184 HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213184LP HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213184RB HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413184 HMGCR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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