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Human HMGCR activation kit by CRISPRa

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SKU
GA102151
HMGCR CRISPRa kit - CRISPR gene activation of human 3-hydroxy-3-methylglutaryl-CoA reductase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA377139 HMGCR Rabbit polyclonal Antibody
100 ul
$410.00
RC213184 HMGCR (Myc-DDK-tagged)-Human 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), transcript variant 1
10 ug
$1,219.00

Other products for "HMGCR"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HMGCR
Locus ID 3156
Components

GA102151G1, HMGCR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102151G2, HMGCR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102151G3, HMGCR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000859, NM_001130996, NM_001364187
UniProt ID P04035
Synonyms LDLCQ3
Summary HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Aug 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN213184 HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213184BN HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213184LP HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213184RB HMGCR - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413184 HMGCR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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